3688-75-3
Chemical Structure
Neokestose
- CAS No.: 3688-75-3
- Formula:C18H32O16
- Molecular Weight:504.44
InChIKey: HQFMTRMPFIZQJF-OESPXIITSA-N
SMILES: OC[C@]1(O[C@@H]([C@H]([C@@H]1O)O)CO)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@@]3(O[C@@H]([C@H]([C@@H]3O)O)CO)CO
Biological Activity: Neokestose is an orally active 6G-series fructooligosaccharide with both sucrase inhibitor and antiproliferative activities. Neokestose inhibits the activity of the NF-κB signaling pathway, reduces the expression of cyclin D1 and COX-2, induces apoptosis, and disrupts the cell cycle. Neokestose can be used in research related to melanoma, colorectal cancer, obesity and diabetes[1][2][3][4][5][6][7].
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Neokestose | Neokestose is an orally active 6G-series fructooligosaccharide with both sucrase inhibitor and antiproliferative activities. Neokestose inhibits the activity of the NF-κB signaling pathway, reduces the expression of cyclin D1 and COX-2, induces apoptosis, and disrupts the cell cycle. Neokestose can be used in research related to melanoma, colorectal cancer, obesity and diabetes. | |||||||||||||||||||||
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References
- [1]. Sato K, et al. Neokestose suppresses the increase in plasma glucose caused by oral administration of sucrose in a streptozotocin‑induced diabetic rat. Scientific reports. 2024 Jul 19;14(1):16658. [Content Brief]
- [2]. Wu JS, et al. Neokestose suppresses the growth of human melanoma A2058 cells via inhibition of the nuclear factor‑κB signaling pathway. Molecular medicine reports. 2017 Jul;16(1):295-300. [Content Brief]
- [3]. Lee SM, et al. Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2. Molecular medicine reports. 2015 Jul;12(1):1114-8. [Content Brief]
- [4]. Leangnim N, et al. Sequential fermentative production, physicochemical, and prebiotic properties of purified neokestose using Daw longan (Dimocarpus longan L. cv. Daw) as the sole substrate. Carbohydr Polym Technol Appl. 2025;11:100951.
- [5]. Kilian S, et al. The effects of the novel bifidogenic trisaccharide, neokestose, on the human colonic microbiota. World J Microbiol Biotechnol. 2002;18(7):637-644.
- [6]. Kritzinger SM, et al. The effect of production parameters on the synthesis of the prebiotic trisaccharide, neokestose, by Xanthophyllomyces dendrorhous (Phaffia rhodozyma). Enzyme Microb Technol. 2003;32(6):728-737.
- [7]. Xu Q, et al. Purification and biochemical characterization of a novel β-fructofuranosidase from Penicillium oxalicum with transfructosylating activity producing neokestose. Process Biochem. 2015;50(8):1207-1215.
