368860-21-3
Chemical Structure
Arimoclomol citrate
Synonym(s): BRX-220 citrate
- CAS No.: 368860-21-3
- Formula:C20H28ClN3O10
- Molecular Weight:505.90
IUPAC Name: (R,Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: XSENLDLUMVYRET-NIOGVPEESA-N
SMILES: Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.O=C(CC(C(O)=O)(O)CC(O)=O)O
Biological Activity: Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Arimoclomol citrate | 99.76% | Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C. | ||||||||||||||||||||
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References
- [1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]
- [2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]
