369631-68-5
369631-68-5
Chemical Structure
Bragsin1
- CAS No.: 369631-68-5
- Formula:C11H6F3NO4
- Molecular Weight:273.16
IUPAC Name: 6-methyl-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one
InChIKey: WEUSXIBCGCFOQR-UHFFFAOYSA-N
SMILES: O=C1C=C(C(F)(F)F)OC2=CC=C(C)C([N+]([O-])=O)=C21
Biological Activity: Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bragsin1 | 99.91% | Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity. | ||||||||||||||||||||
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Bragsin1 (Standard) | ≥98% | Bragsin1 (Standard) is the analytical standard of Bragsin1 (HY-111549). This product is intended for research and analytical applications. Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity. | ||||||||||||||||||||
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