372491-73-1
Chemical Structure
DTS-201 sodium
- CAS No.: 372491-73-1
- Formula:C49H64N5NaO18
- Molecular Weight:1034.04
InChIKey: QMXMSDAJWIGVMO-VAWHKMFHSA-M
SMILES: O=C(O[Na])CCC(NCCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@H]2C[C@@](C(CO)=O)(O)CC3=C2C(O)=C(C(C(C(OC)=CC=C4)=C4C5=O)=O)C5=C3O)C1)=O)=O)=O)=O)=O
Biological Activity: DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer[1].
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DTS-201 sodium | DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer. | |||||||||||||||||||||
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