372523-75-6
372523-75-6
Chemical Structure
TCS-OX2-29
- CAS No.: 372523-75-6
- Formula:C23H31N3O3
- Molecular Weight:397.51
IUPAC Name: (S)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-2-((pyridin-4-ylmethyl)amino)butan-1-one
InChIKey: COFVZFLCAOUMJT-OAQYLSRUSA-N
SMILES: CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O
Biological Activity: TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2].
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TCS-OX2-29 | 99.17% | TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. | ||||||||||||||||||||
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TCS-OX2-29 (Standard) | ≥98% | TCS-OX2-29 (Standard) is the analytical standard of TCS-OX2-29 (HY-100452). This product is intended for research and analytical applications. TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. | ||||||||||||||||||||
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References
- [1]. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9. [Content Brief]
- [2]. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363. [Content Brief]
