37271-16-2
Chemical Structure
Sennoside C
- CAS No.: 37271-16-2
- Formula:C42H40O19
- Molecular Weight:848.76
IUPAC Name: 4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-5,5'-bis((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-9,9',10,10'-tetrahydro-[9,9'-bianthracene]-2-carboxylic acid
InChIKey: ZFWOUNNKSHIAFK-UHFFFAOYSA-N
SMILES: OC(C(O)C1O)C(OC1CO)OC2=CC=CC(C(C(C3=CC(CO)=CC(O)=C3C4=O)C5=C4C(OC(C(C(O)C6O)O)OC6CO)=CC=C5)C7=CC(C(O)=O)=CC(O)=C87)=C2C8=O
Biological Activity: Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases[1][2][3].
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Sennoside C | 99.63% | Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases. | ||||||||||||||||||||
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Sennoside C (Standard) | ≥98% | Sennoside C (Standard) is the analytical standard of Sennoside C (HY-N1972). This product is intended for research and analytical applications. Sennoside C is an orally active component of the traditional Chinese medicine Sennae Folium. Sennoside C can bind to human lysozyme and inhibit its amyloid fibrosis (IC50: 186.20 μM). Sennoside C has certain purgative activity. Sennoside C can be used in the research of diarrhea and anti-amyloid related diseases. | ||||||||||||||||||||
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References
- [1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]
- [2]. Gao W, et al. Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism. Int J Biol Macromol. 2021 May 1;178:424-433. [Content Brief]
- [3]. Kisa K, et al. Potentiating effect of sennoside C on purgative activity of sennoside A in mice. Planta Med. 1981 Jul;42(3):302-3. [Content Brief]
