374567-94-9
374567-94-9
Chemical Structure
Hi 76-0079
Synonym(s): NNC0076-0079; 76-0079
- CAS No.: 374567-94-9
- Formula:C11H13ClN2O3
- Molecular Weight:256.69
IUPAC Name: 4-chlorophenyl morpholinocarbamate
InChIKey: CJKVBAQMCNYASH-UHFFFAOYSA-N
SMILES: O=C(NN1CCOCC1)OC2=CC=C(C=C2)Cl
Biological Activity: Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC50 value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism[1][2].
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Hi 76-0079 | 99.82% | Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC50 value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism. | ||||||||||||||||||||
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References
- [1]. Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013 Dec;9(12):785-7. [Content Brief]
- [2]. Sakai K, et al. Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. J Lipid Res. 2014 Oct;55(10):2033-40. [Content Brief]
