375347-20-9
375347-20-9
Chemical Structure
Lamotrigine hydrate
Synonym(s): LTG hydrate; BW430C hydrate
- CAS No.: 375347-20-9
- Formula:C9H9Cl2N5O
- Molecular Weight:274.11
IUPAC Name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine hydrate
InChIKey: KQMWTSFVXFEXDJ-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1.O
Biological Activity: Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al[1][2].
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Lamotrigine hydrate | Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al. | |||||||||||||||||||||
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References
- [1]. M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27(5):490-7. [Content Brief]
- [2]. Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv). Apr-Jun 2011;53(2):57-62. [Content Brief]
