375822-19-8
375822-19-8
Chemical Structure
D-Ala-Lys-AMCA
- CAS No.: 375822-19-8
- Formula:C21H28N4O6
- Molecular Weight:432.47
IUPAC Name: N2-(D-alanyl)-N6-(2-(7-amino-4-methyl-2-oxo-2H-chromen-3-yl)acetyl)-L-lysine
InChIKey: JBMWHNASOBPJQQ-WBMJQRKESA-N
SMILES: NC1=CC=C(C(C)=C(CC(NCCCC[C@H](NC([C@@H](C)N)=O)C(O)=O)=O)C(O2)=O)C2=C1
Biological Activity: D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm)[1][2].
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D-Ala-Lys-AMCA | D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors (Ex/Em = 390/480 nm). | |||||||||||||||||||||
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References
- [1]. Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166. [Content Brief]
- [2]. Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704. [Content Brief]
