376594-67-1
376594-67-1
Chemical Structure
LY450108
- CAS No.: 376594-67-1
- Formula:C19H22F2N2O3S
- Molecular Weight:396.45
IUPAC Name: (R)-3,5-difluoro-N-(4-(1-((1-methylethyl)sulfonamido)propan-2-yl)phenyl)benzamide
InChIKey: ACOXQYLJOQAHST-ZDUSSCGKSA-N
SMILES: FC1=CC(F)=CC(C(NC2=CC=C([C@@H](C)CNS(C(C)C)(=O)=O)C=C2)=O)=C1
Biological Activity: LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY450108 | 99.51% | LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research. | ||||||||||||||||||||
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LY450108 (Standard) | ≥98% | LY450108 (Standard) is the analytical standard of LY450108 (HY-10935). This product is intended for research and analytical applications. LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and ParKinson's disease research. | ||||||||||||||||||||
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References
- [1]. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190. [Content Brief]
- [2]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. [Content Brief]
- [3]. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32. [Content Brief]
- [4]. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142. [Content Brief]
