37682-72-7
Chemical Structure
Antipain dihydrochloride
- CAS No.: 37682-72-7
- Formula:C27H46Cl2N10O6
- Molecular Weight:677.62
IUPAC Name: (((2S)-5-guanidino-1-(((2S)-1-((5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxopentan-2-yl)carbamoyl)-L-phenylalanine dihydrochloride
InChIKey: YAHXZYICKJUJEO-PKGYLJHQSA-N
SMILES: OC([C@@H](NC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O.[H]Cl.[H]Cl
Biological Activity: Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Antipain dihydrochloride | 99.9% | Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice. | ||||||||||||||||||||
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References
- [1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53. [Content Brief]
- [2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6. [Content Brief]
- [3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76. [Content Brief]
- [4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626. [Content Brief]
