37718-11-9
37718-11-9
Chemical Structure
4-Carboxypyrazole
- CAS No.: 37718-11-9
- Formula:C4H4N2O2
- Molecular Weight:112.09
IUPAC Name: 1H-pyrazole-4-carboxylic acid
InChIKey: IMBBXSASDSZJSX-UHFFFAOYSA-N
SMILES: O=C(C1=CNN=C1)O
Biological Activity: 4-Carboxypyrazole is a pyrazole metabolite and a human liver alcohol dehydrogenase ligand. It is a metabolite of 4-methylpyrazole in mice and rats and does not inhibit the enzyme when methanol is used as a substrate. 4-Carboxypyrazole can be used in studies related to alcohol dehydrogenase metabolism[1][2][3].
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4-Carboxypyrazole | 99.49% | 4-Carboxypyrazole is a pyrazole metabolite and a human liver alcohol dehydrogenase ligand. It is a metabolite of 4-methylpyrazole in mice and rats and does not inhibit the enzyme when methanol is used as a substrate. 4-Carboxypyrazole can be used in studies related to alcohol dehydrogenase metabolism. | ||||||||||||||||||||
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4-Carboxypyrazole (Standard) | ≥98% | 4-Carboxypyrazole (Standard) is the analytical standard of 4-Carboxypyrazole (HY-W002065). This product is intended for research and analytical applications. 4-Carboxypyrazole is a pyrazole metabolite and a human liver alcohol dehydrogenase ligand. It is a metabolite of 4-methylpyrazole in mice and rats and does not inhibit the enzyme when methanol is used as a substrate. 4-Carboxypyrazole can be used in studies related to alcohol dehydrogenase metabolism. | ||||||||||||||||||||
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References
- [1]. Pietruszko R. Human liver alcohol dehydrogenase--inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Biochem Pharmacol. 1975 Sep 1;24(17):1603-7.
- [2]. Fu HR, et al. A stable zinc-4-carboxypyrazole framework with high uptake and selectivity of light hydrocarbons. Dalton transactions (Cambridge, England : 2003). 2015 Feb 14;44(6):2893-6.
- [3]. Blomstrand R, et al. Studies on the metabolism of LADH-inhibitor 4-methylpyrazole in the rat. Life Sci. 1973 Jul 16;13(2):107-12.
