377731-45-8
377731-45-8
Chemical Structure
NS-220
- CAS No.: 377731-45-8
- Formula:C21H27NO5
- Molecular Weight:373.44
IUPAC Name: (2s,5s)-2-methyl-5-(4-(5-methyl-2-(p-tolyl)oxazol-4-yl)butyl)-1,3-dioxane-2-carboxylic acid
InChIKey: IMYPSTHZBIWMNA-NBEIKUQISA-N
SMILES: O=C([C@]1(C)OC[C@H](CCCCC2=C(C)OC(C3=CC=C(C)C=C3)=N2)CO1)O
Biological Activity: NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes[1].
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NS-220 | NS-220 is an orally active PPARα agonist with high subtype selectivity, with EC50 values of 1.9×10-8 M, 9.6×10-6 M and >10-4 M for PPARα, PPAR γ and PPARδ, respectively. NS-220 is used in the research for hyperlipidemia or metabolic disorders in type-2 diabetes. | |||||||||||||||||||||
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References
- [1]. Kenji Kuwabara, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. J Pharmacol Exp Ther. 2004 Jun;309(3):970-7. [Content Brief]
