377755-95-8
377755-95-8
Chemical Structure
CJ-14897
- CAS No.: 377755-95-8
- Formula:C12H15NO5
- Molecular Weight:253.25
InChIKey: CTJGPKROOIGCCC-WRWORJQWSA-N
SMILES: CC(O[C@@H](C)[C@H](C1=CN=C(C(OC)=O)C=C1)O)=O
Biological Activity: CJ-14897 is a cytokine production inhibitor, with IC50 values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC50 of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624[1][2].
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CJ-14897 | CJ-14897 is a cytokine production inhibitor, with IC50 values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC50 of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624. | |||||||||||||||||||||
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References
- [1]. Ichikawa K, et al. Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp. J Antibiot (Tokyo). 2001;54(9):703-709. [Content Brief]
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[2]. Braddock M, Quinn A. Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention. Nature reviews Drug discovery. 2004 Apr 1;3(4):330-40.
