379215-96-0
Chemical Structure
LY310762 free base
- CAS No.: 379215-96-0
- Formula:C24H27FN2O2
- Molecular Weight:394.48
InChIKey: KDXISMANFPJVJY-UHFFFAOYSA-N
SMILES: O=C(C1CCN(CC1)CCN2C(C(C)(C)C3=C2C=CC=C3)=O)C4=CC=C(C=C4)F
Biological Activity: LY310762 free base is a selective 5-HT1D receptor antagonist with a Ki value of 249 nM for the guinea pig receptor. LY310762 free base blocks presynaptic 5-HT1D autoreceptors and enhances potassium-stimulated [3H]5-HT outflow from guinea pig cortical slices. LY310762 free base abolishes the inhibitory effect of 5-CT (HY-135555)/L-694,247 (HY-101208) on sympathetic nerve-induced renal vasoconstriction mediated by prejunctional 5-HT1D receptors. LY310762 free base potentiates the increase in extracellular 5-HT concentration induced by Fluoxetine (HY-B0102). LY310762 free base is used in research related to depression and diabetic nephropathy[1][2][3].
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LY310762 free base | LY310762 free base is a selective 5-HT1D receptor antagonist with a Ki value of 249 nM for the guinea pig receptor. LY310762 free base blocks presynaptic 5-HT1D autoreceptors and enhances potassium-stimulated [3H]5-HT outflow from guinea pig cortical slices. LY310762 free base abolishes the inhibitory effect of 5-CT (HY-135555)/L-694,247 (HY-101208) on sympathetic nerve-induced renal vasoconstriction mediated by prejunctional 5-HT1D receptors. LY310762 free base potentiates the increase in extracellular 5-HT concentration induced by Fluoxetine (HY-B0102). LY310762 free base is used in research related to depression and diabetic nephropathy. | |||||||||||||||||||||
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References
- [1]. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. European journal of pharmacology. 2004 Jun 16;493(1-3):85-93. [Content Brief]
- [2]. Fernández-González JF, et al. Renal Sympathetic Hyperactivity in Diabetes Is Modulated by 5-HT Receptor Activation via NO Pathway. International journal of molecular sciences. 2023 Jan 10;24(2):1378.
- [3]. García-Pedraza JÁ, et al. Vascular sympathetic neurotransmission and its serotonergic regulation are modified by chronic fluoxetine treatment. Journal of pharmacological sciences. 2021 Sep;147(1):48-57.
