38030-57-8
38030-57-8
Chemical Structure
all-trans-4-Oxoretinoic acid
Synonym(s): all-trans 4-Keto Retinoic Acid
- CAS No.: 38030-57-8
- Formula:C20H26O3
- Molecular Weight:314.42
IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
InChIKey: GGCUJPCCTQNTJF-FRCNGJHJSA-N
SMILES: CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O
Biological Activity: all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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all-trans-4-Oxoretinoic acid | 98.03% | all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). | ||||||||||||||||||||
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all-trans-4-Oxoretinoic acid (Standard) | ≥98% | all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). | ||||||||||||||||||||
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4-Oxoretinoic acid-d3 | 4-Oxoretinoic acid-d3 is the deuterium labeled 4-Oxoretinoic acid. | |||||||||||||||||||||
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13-cis-4-Oxoretinoic acid | 95.41% | 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma. | ||||||||||||||||||||
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Methyl 13-cis-4-oxoretinoate | 96.77% | Methyl 13-cis-4-oxoretinoate (Compound 4b) is a retinoic acid receptors (RARs) agonist. Methyl 13-cis-4-oxoretinoate is promising for research of dermatological diseases (e.g., disorders related to abnormal differentiation of keratinocytes) and cancers. | ||||||||||||||||||||
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4-Hydroxyretinoic acid | 94.58% | 4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation. | ||||||||||||||||||||
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Retinoic acid | 99.81% | Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. | ||||||||||||||||||||
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Isotretinoin (Standard) | 98.24% | Isotretinoin (Standard) is the analytical standard of Isotretinoin. This product is intended for research and analytical applications. Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity. | ||||||||||||||||||||
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9-cis-Retinoic acid (Standard) | ≥98% | 9-cis-Retinoic acid (Standard) is the analytical standard of 9-cis-Retinoic acid. This product is intended for research and analytical applications. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities. | ||||||||||||||||||||
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Methyl-4-oxoretinoate | 98.75% | Methyl-4-oxoretinoate is a derivative of Retinoic acid (HY-14649). Methyl-4-oxoretinoate inhibits TPA (HY-18739)-induced ornithine decarboxylase (ODC) activity, and carcinogen-induced papillomas in mouse skin. | ||||||||||||||||||||
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all-trans-3,4-Didehydro retinoic acid | 95.0% | All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is a compound with gene-regulating activity that binds to retinoic acid receptors (RARs) and triggers receptor activation. All-trans-3,4-Didehydro retinoic acid plays an important role in skin development and differentiation and has potential anti-tumor and anti-inflammatory properties. All-trans-3,4-Didehydro retinoic acid is also being studied for the inhibition of a variety of diseases, including skin diseases and certain types of cancer. | ||||||||||||||||||||
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4,4-Dimethyl retinoic acid | 95.67% | 4,4-Dimethyl retinoic acid is a kind of biochemical reagent. | ||||||||||||||||||||
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