38048-32-7
38048-32-7
Chemical Structure
Nitrobenzylthioinosine
Synonym(s): NBMPR
- CAS No.: 38048-32-7
- Formula:C17H17N5O6S
- Molecular Weight:419.41
IUPAC Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
InChIKey: DYCJFJRCWPVDHY-LSCFUAHRSA-N
SMILES: OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)SCC4=CC=C([N+]([O-])=O)C=C4)O1)O)O
Biological Activity: Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nitrobenzylthioinosine | 98.90% | Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier. | ||||||||||||||||||||
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References
- [1]. Lauri Alanko, et al. Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat. J Sleep Res. 2003 Dec;12(4):299-304. [Content Brief]
- [2]. C M Anderson, et al. Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats. Neurosci Lett. 1996 Nov 29;219(3):191-4. [Content Brief]
- [3]. P J Marangos, et al. [3H]nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Eur J Pharmacol. 1982 Dec 3;85(3-4):359-60. [Content Brief]
