38376-29-3
38376-29-3
Chemical Structure
VU0420373
- CAS No.: 38376-29-3
- Formula:C15H11FN2O
- Molecular Weight:254.26
IUPAC Name: 2-(5-(2-fluorophenyl)-1H-pyrazol-3-yl)phenol
InChIKey: SJPGLKXXUIEFLO-UHFFFAOYSA-N
SMILES: OC1=CC=CC=C1C2=NNC(C3=CC=CC=C3F)=C2
Biological Activity: VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0420373 | 99.67% | VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus. | ||||||||||||||||||||
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VRT-532 | 98.98% | VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis. | ||||||||||||||||||||
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12R-LOX-IN-1 | 12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research. | |||||||||||||||||||||
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SMARCA2-IN-1 | 98.57% | SMARCA2-IN-1 (Compound I-19) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 with IC50 >1000 nM in H1299. | ||||||||||||||||||||
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TrkA-IN-7 | TrkA-IN-7 (Compound 4) is an inhibitor of Tropomyosin Receptor Kinase A (TrkA) with a Kd value of 40 μM. | |||||||||||||||||||||
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PBRM1/SMARCA2,4-ligand-1 | PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410). | |||||||||||||||||||||
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MLS000099089 | MLS000099089 is a 12/15-lipoxygenase (12/15-LOX) inhibitor with IC50 values of 3.4 μM and 10 μM for human and mice 12/15-LOX, respectively. MLS000099089 displays higher selectivity for 12/15-LOX over 5-LOX and COX-2. MLS000099089 can be used for the study of stroke. | |||||||||||||||||||||
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Multi-target kinase-IN-10 | Multi-target kinase-IN-10 (Compound 6l) is an orally active, blood-brain barrier-permeable, selective, reversible, and competitive MAO-B inhibitor with an IC50 of 0.0053 μM. Multi-target kinase-IN-10 competes with substrates for binding to the active site of MAO-B, chelates Cu2+ ions, inhibits Cu2+-induced ROS production, and reduces the release of NO, TNF-α, and IL-1β. Multi-target kinase-IN-10 ameliorates Parkinson's disease. | |||||||||||||||||||||
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2-NP | 99.55% | 2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells. | ||||||||||||||||||||
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2,2'-Pyridine-2,6-diyldiphenol | 2,2'-(Pyridine-2,6-diyl)diphenol is a metal-organic framework (MOF). | |||||||||||||||||||||
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2-(2′-Hydroxyphenyl)benzimidazole | 99.92% | 2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems. | ||||||||||||||||||||
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