384832-91-1
Chemical Structure
18:1 PE CF
Synonym(s): 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
- CAS No.: 384832-91-1
- Formula:C62H94N3O14P
- Molecular Weight:1136.40
IUPAC Name: cyclohexan-d11-1-ol
InChIKey: SYTVVMALVQLZIE-NFESXEJCSA-N
SMILES: O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(C(NCCOP(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O)=O)C=C51.N.N
Biological Activity: 18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm)[1][2][3][4][5].
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18:1 PE CF | 18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm). | |||||||||||||||||||||
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References
- [1]. Bitbol AF, et al. Lipid membrane deformation in response to a local pH modification: theory and experiments. Soft Matter. 2012;8(30):6073-6083.
- [2]. Hirsch-Lerner D, et al. Effect of "helper lipid" on lipoplex electrostatics. Biochim Biophys Acta. 2005;1714(2):71-84. [Content Brief]
- [3]. Wu Y, et al. The promoted delivery of RRM2 siRNA to vascular smooth muscle cells through liposome-polycation-DNA complex conjugated with cell penetrating peptides. Biomed Pharmacother. 2018;103:982-988. [Content Brief]
- [4]. Chakraborty I, et al. Colloidal joints with designed motion range and tunable joint flexibility. Nanoscale. 2017;9(23):7814-7821. [Content Brief]
- [5]. Huang X, et al. Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells. World J Surg Oncol. 2017;15(1):167. Published 2017 Aug 30. [Content Brief]
