384860-40-6
384860-40-6
Chemical Structure
ATC12
- CAS No.: 384860-40-6
- Formula:C28H29NO3
- Molecular Weight:427.53
InChIKey: WKZZXGSPJLZUAF-UHFFFAOYSA-N
SMILES: CC(C)(C1=CC(C2=CC(C(O)=O)=C3C4=CC=CC=C4C=CC3=N2)=CC(C(C)(C)C)=C1O)C
Biological Activity: ATC12 is a Aurora-A kinase inhibitor. ATC12 binds to Aurora-A and competes with TPX2 for binding to disrupt the Aurora-A/TPX2 interaction. ATC12 inhibits cancer cell proliferation, induces apoptosis and cellular senescence. ATC12 can be used in the research of breast cancer[1].
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ATC12 | ATC12 is a Aurora-A kinase inhibitor. ATC12 binds to Aurora-A and competes with TPX2 for binding to disrupt the Aurora-A/TPX2 interaction. ATC12 inhibits cancer cell proliferation, induces apoptosis and cellular senescence. ATC12 can be used in the research of breast cancer. | |||||||||||||||||||||
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