3849-21-6
3849-21-6
Chemical Structure
Ethyl 2-cyano-2-(hydroxyimino)acetate
- CAS No.: 3849-21-6
- Formula:C5H6N2O3
- Molecular Weight:142.11
IUPAC Name: ethyl (E)-2-cyano-2-(hydroxyimino)acetate
InChIKey: LCFXLZAXGXOXAP-QPJJXVBHSA-N
SMILES: O=C(OCC)/C(C#N)=N/O
Biological Activity: Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) is a peptide coupling additive. Ethyl 2-cyano-2-(hydroxyimino) acetate suppresses racemization during peptide coupling and improves the coupling efficiency of both solution-phase and solid-phase peptide synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ethyl 2-cyano-2-(hydroxyimino)acetate | 99.89% | Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) is a peptide coupling additive. Ethyl 2-cyano-2-(hydroxyimino) acetate suppresses racemization during peptide coupling and improves the coupling efficiency of both solution-phase and solid-phase peptide synthesis. | ||||||||||||||||||||
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References
- [1]. Dev D, et al. An unexpected involvement of ethyl-2-cyano-2-(hydroxyimino) acetate cleaved product in the promotion of the synthesis of nitriles from aldoximes: a mechanistic perception[J]. Tetrahedron Letters, 2013, 54(33): 4397-4400.
- [2]. Khattab S N. Ethyl 2-Cyano-2-(hydroxyimino) acetate (Oxyma): an efficient and convenient additive used with Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) to replace 1-Hydroxybenzotriazole (HOBt) and 1-Hydroxy-7-azabenzotriazole (HOAt) during peptide synthesis[J]. Bulletin of the Chemical Society of Japan, 2010, 83(11): 1374-1379.
