385425-03-6
Chemical Structure
IBS008738
- CAS No.: 385425-03-6
- Formula:C22H22N4O2
- Molecular Weight:374.44
IUPAC Name: (E)-(4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone
InChIKey: UCDKLMTYEDPEMY-HZHRSRAPSA-N
SMILES: O=C(C1=C(/N=C/N2CCOCC2)N=CN1C3=CC=C(C)C=C3)C4=CC=CC=C4
Biological Activity: IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IBS008738 | 98.22% | IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. | ||||||||||||||||||||
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References
- [1]. Yang Z, et al. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol Cell Biol. 2014;34(9):1607-1621. [Content Brief]
- [2]. Zou R, et al. TAZ Activator Is Involved in IL-10-Mediated Muscle Responses in an Animal Model of Traumatic Brain Injury. Inflammation. 2017;40(1):100-105. [Content Brief]
