38937-66-5
38937-66-5
Chemical Structure
Suberoyl bis-hydroxamic acid
Synonym(s): Suberohydroxamic acid; SBHA
- CAS No.: 38937-66-5
- Formula:C8H16N2O4
- Molecular Weight:204.22
IUPAC Name: N1,N8-dihydroxyoctanediamide
InChIKey: IDQPVOFTURLJPT-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCCC(NO)=O
Biological Activity: Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively[1].Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways[2].Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC)[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Suberoyl bis-hydroxamic acid | 95.0% | Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC). | ||||||||||||||||||||
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References
- [1]. Jiri Neuzil, et al. Sensitization of Mesothelioma to TRAIL Apoptosis by Inhibition of Histone Deacetylase: Role of Bcl-xL Down-Regulation. Biochem Biophys Res Commun. 2004 Jan 30;314(1):186-91. [Content Brief]
- [2]. V M Richon, et al. A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases.Proc Natl Acad Sci U S A [Content Brief]
- [3]. Li Ning, et al. Suberoyl Bishydroxamic Acid Activates notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma. Ann Surg Oncol. 2008 Sep;15(9):2600-5. [Content Brief]
