390362-78-4
390362-78-4
Chemical Structure
RHPS4
- CAS No.: 390362-78-4
- Formula:C23H20F2N2O4S
- Molecular Weight:458.48
IUPAC Name: 3,11-difluoro-6,8,13-trimethyl-8H-quinolino[4,3,2-kl]acridin-13-ium methyl sulfate
InChIKey: VRWGYMXWYZBBGF-UHFFFAOYSA-M
SMILES: O=S([O-])(OC)=O.FC1=CC=C2C(C3=[N+](C)C4=C(C=C(C=C4)F)C5=C3C(N2C)=CC(C)=C5)=C1
Biological Activity: RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RHPS4 | 99.88% | RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer. | ||||||||||||||||||||
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RHPS4 (Standard) | ≥98% | RHPS4 (Standard) is the analytical standard of RHPS4 (HY-101089). This product is intended for research and analytical applications. RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer. | ||||||||||||||||||||
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References
- [1]. Jennifer C Cookson, et al. Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents. Mol Pharmacol. 2005 Dec;68(6):1551-8. [Content Brief]
- [2]. Erica Salvati, et al. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest. 2007 Nov;117(11):3236-47. [Content Brief]
