3918-87-4
Chemical Structure
Phenylalanylalanine
Synonym(s): Phe-ala
- CAS No.: 3918-87-4
- Formula:C12H16N2O3
- Molecular Weight:236.27
IUPAC Name: L-phenylalanyl-L-alanine
InChIKey: MIDZLCFIAINOQN-WPRPVWTQSA-N
SMILES: C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)N)=O
Biological Activity: Phenylalanylalanine (Phe-ala) is an enkephalinase inhibitor and belongs to the class of dipeptides. Phenylalanylalanine inhibits dipeptidyl carboxypeptidase-mediated enkephalin degradation by cleaving the Gly3-Phe4 bond, and when co-administered with Leu-enkephalin, it produces analgesic effects with a synergistic enhancement, which can be reversed by Naloxone (HY-17417A). Phenylalanylalanine can be used in pain-related research[1][2].
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Phenylalanylalanine | 99.47% | Phenylalanylalanine (Phe-ala) is an enkephalinase inhibitor and belongs to the class of dipeptides. Phenylalanylalanine inhibits dipeptidyl carboxypeptidase-mediated enkephalin degradation by cleaving the Gly3-Phe4 bond, and when co-administered with Leu-enkephalin, it produces analgesic effects with a synergistic enhancement, which can be reversed by Naloxone (HY-17417A). Phenylalanylalanine can be used in pain-related research. | ||||||||||||||||||||
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Phenylalanylalanine (Standard) | ≥98% | Phenylalanylalanine (Standard) (Phe-ala (Standard)) is the analytical standard of Phenylalanylalanine (HY-W009602). This product is intended for research and analytical applications. Phenylalanylalanine is an enkephalinase inhibitor and belongs to the class of dipeptides. Phenylalanylalanine inhibits dipeptidyl carboxypeptidase-mediated enkephalin degradation by cleaving the Gly3-Phe4 bond, and when co-administered with Leu-enkephalin, it produces analgesic effects with a synergistic enhancement, which can be reversed by Naloxone (HY-17417A). Phenylalanylalanine can be used in pain-related research. | ||||||||||||||||||||
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References
- [1]. Borin G, et al. Analgesic properties of N-terminal substituted phenylalanyl-alanine. Life sciences. 1983 Oct 17;33(16):1575-80. [Content Brief]
- [2]. Larionov R A, et al. Strategy For Solid-State Synthesis of the Cyclic Dipeptide from Phenylalanyl-Alanine and Alanyl-Phenylalanine. Russian Journal of General Chemistry, 2024, 94: 3113-3125.
