393110-43-5
393110-43-5
Chemical Structure
VU0092273
- CAS No.: 393110-43-5
- Formula:C20H19NO2
- Molecular Weight:305.37
IUPAC Name: (4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)methanone
InChIKey: FPDBSDNGFNDSSK-UHFFFAOYSA-N
SMILES: O=C(N1CCC(O)CC1)C2=CC=C(C#CC3=CC=CC=C3)C=C2
Biological Activity: VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0092273 | 99.51% | VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM. | ||||||||||||||||||||
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References
- [1]. Douglas J Sheffler, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5. [Content Brief]
- [2]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. [Content Brief]
