39391-39-4
Chemical Structure
Nocardicin A
- CAS No.: 39391-39-4
- Formula:C23H24N4O9
- Molecular Weight:500.46
IUPAC Name: O-(4-((Z)-2-(((S)-1-((R)-carboxy(4-hydroxyphenyl)methyl)-2-oxoazetidin-3-yl)amino)-1-(hydroxyimino)-2-oxoethyl)phenyl)-D-homoserine
InChIKey: CTNZOGJNVIFEBA-UPSUJEDGSA-N
SMILES: OC([C@@H](C1=CC=C(C=C1)O)N2C([C@H](C2)NC(/C(C3=CC=C(C=C3)OCC[C@@H](N)C(O)=O)=N\O)=O)=O)=O
Biological Activity: Nocardicin A is a monocyclic β-lactam antibiotic with broad-spectrum activity against Gram-negative bacteria. Nocardicin A inhibits bacterial cell wall synthesis and synergistically stimulates the phagocytic and bactericidal functions of polymorphonuclear leukocytes (PMN). Nocardicin A can be used in research on Gram-negative bacterial infections[1][2][3][4][5][6][7][8].
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Nocardicin A | Nocardicin A is a monocyclic β-lactam antibiotic with broad-spectrum activity against Gram-negative bacteria. Nocardicin A inhibits bacterial cell wall synthesis and synergistically stimulates the phagocytic and bactericidal functions of polymorphonuclear leukocytes (PMN). Nocardicin A can be used in research on Gram-negative bacterial infections. | |||||||||||||||||||||
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References
- [1]. Engelbrecht A, et al. Natural Products from Nocardia and Their Role in Pathogenicity. Microbial physiology. 2021;31(3):217-232.
- [2]. Aoki H, et al. Nocardicin A, a new monocyclic β-lactam antibiotic I. Discovery, isolation and characterization. The Journal of antibiotics. 1976;29(5):492-500. [Content Brief]
- [3]. Mine Y, et al. Nocardicin A, a new monocyclic beta-lactam antibiotic V. In vivo evaluation. J Antibiot (Tokyo). 1977 Nov;30(11):932-7.
- [4]. KATAYAMA N, et al. Formadicins, new monocyclic β-lactam antibiotics of bacterial origin I. Taxonomy, fermentation and biological activities. The Journal of antibiotics. 1985;38(9):1117-27. [Content Brief]
- [5]. Hashimoto M, et al. Nocardicin A and B, monocyclic. beta.-lactam antibiotics from a Nocardia species. Journal of the American Chemical Society. 1976 May;98(10):3023-5.
- [6]. Berenguer J, et al. Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam. Antimicrobial agents and chemotherapy. 1982 Feb;21(2):195-200.
- [7]. Angehrn P, et al. Synergistic antibacterial activity between L-norvalyl-L-1-aminoethylphosphonic acid and nocardicin A. Antimicrobial agents and chemotherapy. 1984 May;25(5):607-11.
- [8]. Banks RM, et al. Therapeutic significance of nocardicin A stimulation of phagocyte function in experimental Pseudomonas aeruginosa infection. British journal of experimental pathology. 1983 Apr;64(2):231-7.
