395639-53-9
395639-53-9
Chemical Structure
Aselizumab
Synonym(s): HuDreg-55
- CAS No.: 395639-53-9
- Formula:N/A
- Molecular Weight:(144.74 kDa)
IUPAC Name: N-((1r,4r)-4-aminocyclohexyl)-4-chlorobenzamide hydrochloride
SMILES: [Aselizumab]
Biological Activity: Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aselizumab | 99.76% | Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma. | ||||||||||||||||||||
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References
- [1]. Seekamp A, et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med. 2004 Oct;32(10):2021-8. [Content Brief]
- [2]. Rahman I, et al. L-selectin regulates human neutrophil transendothelial migration. J Cell Sci. 2021 Feb 8;134(3):jcs250340. [Content Brief]
