402473-54-5
402473-54-5
Chemical Structure
ONO-AE3-208
Synonym(s): AE 3-208
- CAS No.: 402473-54-5
- Formula:C24H21FN2O3
- Molecular Weight:404.43
IUPAC Name: 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid
InChIKey: MTDIMKNAJUQTIO-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(NC(C(C2=C3C=CC=CC3=C(F)C=C2)C)=O)=C1)CCCC(O)=O
Biological Activity: ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ONO-AE3-208 | 98.97% | ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. | ||||||||||||||||||||
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References
- [1]. Kenji Kabashima, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109(7):883-93. [Content Brief]
- [2]. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8. [Content Brief]
