404920-28-1
Chemical Structure
S-40503
- CAS No.: 404920-28-1
- Formula:C15H23N3O3
- Molecular Weight:293.36
IUPAC Name: 2-(4-(dimethylamino)-6-nitro-1,2,3,4-tetrahydroquinolin-2-yl)-2-methylpropan-1-ol
InChIKey: YNYAUBNZRZVNLX-UHFFFAOYSA-N
SMILES: CC(CO)(C)C1CC(N(C)C)C2=CC([N+]([O-])=O)=CC=C2N1
Biological Activity: S-40503 is a tissue-selective androgen receptor (AR) agonist with a Ki of 14.9 nM for rat AR. S-40503 binds to AR with high specificity, exerts full agonistic effects in bone and muscle, acts as a partial agonist in the prostate, and preferentially targets anabolic tissues rather than androgen-dependent tissues. S-40503 can be used in the research of osteoporosis[1][2][3][4].
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S-40503 | S-40503 is a tissue-selective androgen receptor (AR) agonist with a Ki of 14.9 nM for rat AR. S-40503 binds to AR with high specificity, exerts full agonistic effects in bone and muscle, acts as a partial agonist in the prostate, and preferentially targets anabolic tissues rather than androgen-dependent tissues. S-40503 can be used in the research of osteoporosis. | |||||||||||||||||||||
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References
- [1]. Hanada K, et al. Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. Biological & pharmaceutical bulletin. 2003 Nov;26(11):1563-9. [Content Brief]
- [2]. Gao W, et al. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. Pharmaceutical research. 2006 Aug;23(8):1641-58.
- [3]. Kearbey JD, et al. Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharmaceutical research. 2009 Nov;26(11):2471-7.
- [4]. Kearbey JD, et al. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharmaceutical research. 2007 Feb;24(2):328-35.
