4070-42-2
Chemical Structure
8-Hydroxydihydrochelerythrine
- CAS No.: 4070-42-2
- Formula:C21H19NO5
- Molecular Weight:365.38
InChIKey: RATMHCJTVBHJSU-UHFFFAOYSA-N
SMILES: OC1C2=C(C3=CC=C4C=C5OCOC5=CC4=C3N1C)C=CC(OC)=C2OC
Biological Activity: 8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC50=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease[1][2].
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8-Hydroxydihydrochelerythrine | 8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC50=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Cho K M, et al. 8-hydroxydihydrochelerythrine and 8-hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L[J]. Biological and Pharmaceutical Bulletin, 2006, 29(11): 2317-2320.
- [2]. Hu J, et al. Alkaloids from Zanthoxylum nitidum (Roxb.) DC[J]. Biochemical Systematics and Ecology, 2007, 35(2): 114-117.
