410532-55-7
410532-55-7
Chemical Structure
2A/2B Dengue protease substrate
- CAS No.: 410532-55-7
- Formula:C39H68N16O11
- Molecular Weight:937.06
InChIKey: UZCAVGUGGCKEIE-DPFYJSDBSA-N
SMILES: N=C(N)NCCC[C@H](NC(C)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(NC1=CC=C(C=C1)[N+]([O-])=O)=O)=O)=O)=O)=O)=O
Biological Activity: 2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for the Dengue NS2B-NS3 protease, with a Ki value of 12 μM. 2A/2B Dengue protease substrate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease[1][2].
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2A/2B Dengue protease substrate | 2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for the Dengue NS2B-NS3 protease, with a Ki value of 12 μM. 2A/2B Dengue protease substrate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease. | |||||||||||||||||||||
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References
- [1]. Leung D, et al. Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. J Biol Chem. 2001 Dec 7;276(49):45762-71. [Content Brief]
- [2]. Nitsche C, et al. Biochemistry and medicinal chemistry of the dengue virus protease. Chem Rev. 2014 Nov 26;114(22):11348-81.
