41078-02-8
41078-02-8
Chemical Structure
Enprofylline
- CAS No.: 41078-02-8
- Formula:C8H10N4O2
- Molecular Weight:194.19
IUPAC Name: 3-propyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: SIQPXVQCUCHWDI-UHFFFAOYSA-N
SMILES: O=C1NC(N(CCC)C2=C1NC=N2)=O
Biological Activity: Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Enprofylline | 98.71% | Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease. | ||||||||||||||||||||
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References
- [1]. I Feoktistov, et al. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest. 1995 Oct;96(4):1979-86. [Content Brief]
- [2]. M B Grant, et al. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2068-73. [Content Brief]
- [3]. Jiang-Ning Yang, et al. Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1141-9. [Content Brief]
