41094-88-6
Chemical Structure
Tracazolate
Synonym(s): ICI 136753
- CAS No.: 41094-88-6
- Formula:C16H24N4O2
- Molecular Weight:304.39
IUPAC Name: ethyl 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
InChIKey: PCTRYMLLRKWXGF-UHFFFAOYSA-N
SMILES: O=C(OCC)C1=C(N=C2C(C=NN2CC)=C1NCCCC)C
Biological Activity: Tracazolate (ICI 136753) is an orally active non-benzodiazepine anxiolytic. Tracazolate significantly enhances the binding of the radioligand 3H-flunitrazepam (3H-FLU) to brain tissue benzodiazepine receptors. Tracazolate enhances the binding of γ-aminobutyric acid (GABA) to its receptors. Tracazolate exhibits anticonvulsant activity. Tracazolate can be used in anxiety-related research[1][2].
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Tracazolate | Tracazolate (ICI 136753) is an orally active non-benzodiazepine anxiolytic. Tracazolate significantly enhances the binding of the radioligand 3H-flunitrazepam (3H-FLU) to brain tissue benzodiazepine receptors. Tracazolate enhances the binding of γ-aminobutyric acid (GABA) to its receptors. Tracazolate exhibits anticonvulsant activity. Tracazolate can be used in anxiety-related research. | |||||||||||||||||||||
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References
- [1]. Patel JB, et al. Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur J Pharmacol. 1982;78(3):323-333. [Content Brief]
- [2]. Patel JB, et al. Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622. Pharmacol Biochem Behav. 1988;29(4):775-779. [Content Brief]
