41175-45-5
41175-45-5
Chemical Structure
Coumarin 106
Synonym(s): Coumarin 478
- CAS No.: 41175-45-5
- Formula:C18H19NO2
- Molecular Weight:281.35
IUPAC Name: 2,3,6,7,10,11-hexahydro-1H,5H-cyclopenta[4,5]pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-12(9H)-one
InChIKey: LLSRPENMALNOFW-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5
Biological Activity: Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Coumarin 106 | 99.76% | Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56). | ||||||||||||||||||||
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References
- [1]. Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. [Content Brief]
- [2]. Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. [Content Brief]
