4155-82-2
4155-82-2
Chemical Structure
RDR 02308
- CAS No.: 4155-82-2
- Formula:C19H15N3O3
- Molecular Weight:333.34
IUPAC Name: 5-(furan-2-yl)-3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
InChIKey: DCFSIJLWXJXSQC-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=CO4)C2)C=C1)[O-]
Biological Activity: RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RDR 02308 | 98.0% | RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase. | ||||||||||||||||||||
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TCS PrP Inhibitor 13 (Standard) | TCS PrP Inhibitor 13 (Standard) is the analytical standard of TCS PrP Inhibitor 13 (HY-107662). This product is intended for research and analytical applications. TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis. | |||||||||||||||||||||
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PHPS1 | 99.87% | PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively. | ||||||||||||||||||||
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MLS-573151 | 99.66% | MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42. | ||||||||||||||||||||
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ML141 | 99.96% | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines. | ||||||||||||||||||||
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Rhodblock 1a | Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer. | |||||||||||||||||||||
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ARC12 | 99.0% | ARC12 is a secondary metabolism probe that modulates the production of Streptomyces coelicolor secondary metabolites. ARC12 reduces the production of germicidin. | ||||||||||||||||||||
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Anticancer agent 231 | Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy. | |||||||||||||||||||||
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Topoisomerase I/II inhibitor 7 | Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor. | |||||||||||||||||||||
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COX-2/15-LOX-IN-7 | COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer. | |||||||||||||||||||||
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1,3,5-Triphenyl-2-pyrazoline | 1,3,5-Triphenyl-2-pyrazoline (Compound 12) is a pyrazoline derivative. 1,3,5-Triphenyl-2-pyrazoline exhibits weak cytotoxicity against K562 and Jurkat cells, with an IC50 of greater than 300 μM and 297.7 μM, respectively. 1,3,5-Triphenyl-2-pyrazoline has a predicted human intestinal absorption rate of 100%. | |||||||||||||||||||||
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