419532-92-6
419532-92-6
Chemical Structure
Phenylpyropene C
Synonym(s): S14-95
- CAS No.: 419532-92-6
- Formula:C28H34O5
- Molecular Weight:450.57
IUPAC Name: (3S,4aR,6aR,12aR,12bS)-4,4,6a,12b-tetramethyl-11-oxo-9-phenyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl acetate
InChIKey: MIBRSIZECYPMLX-KZEXJIRGSA-N
SMILES: C[C@@]12[C@]3([H])[C@](OC4=C(C(OC(C5=CC=CC=C5)=C4)=O)C3)(CC[C@@]1([H])C(C)([C@H](CC2)OC(C)=O)C)C
Biological Activity: Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].
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Phenylpyropene C | Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM. | |||||||||||||||||||||
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References
- [1]. Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4. [Content Brief]
- [2]. Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43. [Content Brief]
