42230-55-7
Chemical Structure
Acetylaszonalenin
Synonym(s): LL-S490β
- CAS No.: 42230-55-7
- Formula:C25H25N3O3
- Molecular Weight:415.48
IUPAC Name: (5aS,13aR,14aS)-5-acetyl-14a-(2-methylbut-3-en-2-yl)-5a,13a,14,14a-tetrahydrobenzo[5',6'][1,4]diazepino[1',2':1,5]pyrrolo[2,3-b]indole-7,13(5H,12H)-dione
InChIKey: TXNJQKDZOVFCAQ-XRODADMRSA-N
SMILES: O=C1N2[C@@]([H])(C(NC3=CC=CC=C13)=O)C[C@]4([C@@]2(N(C5=C4C=CC=C5)C(C)=O)[H])C(C)(C=C)C
Biological Activity: Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM[1][2].
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Acetylaszonalenin | Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM. | |||||||||||||||||||||
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References
- [1]. Wen-Bing Yin, et al. Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem. 2009 Jan 2;284(1):100-109. [Content Brief]
- [2]. C J Barrow, et al. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes. J Nat Prod. 1994 Apr;57(4):471-6. [Content Brief]
