423744-89-2
Chemical Structure
BC12
- CAS No.: 423744-89-2
- Formula:C21H19N3O3
- Molecular Weight:361.39
IUPAC Name: (E)-5-((E)-3-(4-(dimethylamino)phenyl)allylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
InChIKey: WSBFTODMEZTVBC-ZOQHSEBNSA-N
SMILES: O=C1NC(/C(C(N1C2=CC=CC=C2)=O)=C\C=C\C3=CC=C(C=C3)N(C)C)=O
Biological Activity: BC12 is a barbituric acid derivative and a phosphodiesterase 7 (PDE7) inhibitor, with an IC50 of 0.77 μM against human targets. BC12 inhibits the enzymatic activity of PDE7, but this activity is not the driver of its immunomodulatory effects on T lymphocytes. BC12 blocks the upregulation of IL-2 transcription in activated T cells. BC12 modulates the transcriptional response of T cells upon stimulation, exerting anti-inflammatory and pro-stress effects. BC12 inhibits the proliferation of primary mouse T cells and the IL-2 secretion of human peripheral blood T lymphocytes. BC12 exerts immunosuppressive and immunomodulatory effects on T lymphocyte function. BC12 can be used in research related to T lymphocyte-mediated diseases[1].
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BC12 | BC12 is a barbituric acid derivative and a phosphodiesterase 7 (PDE7) inhibitor, with an IC50 of 0.77 μM against human targets. BC12 inhibits the enzymatic activity of PDE7, but this activity is not the driver of its immunomodulatory effects on T lymphocytes. BC12 blocks the upregulation of IL-2 transcription in activated T cells. BC12 modulates the transcriptional response of T cells upon stimulation, exerting anti-inflammatory and pro-stress effects. BC12 inhibits the proliferation of primary mouse T cells and the IL-2 secretion of human peripheral blood T lymphocytes. BC12 exerts immunosuppressive and immunomodulatory effects on T lymphocyte function. BC12 can be used in research related to T lymphocyte-mediated diseases. | |||||||||||||||||||||
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