4269-97-0
Chemical Structure
S-Isopropylisothiourea hydrobromide
Synonym(s): S-isopropyl ITU; IPTU
- CAS No.: 4269-97-0
- Formula:C4H11BrN2S
- Molecular Weight:199.11
IUPAC Name: isopropyl carbamimidothioate hydrobromide
InChIKey: SLGVZEOMLCTKRK-UHFFFAOYSA-N
SMILES: NC(SC(C)C)=N.Br
Biological Activity: S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S-Isopropylisothiourea hydrobromide | 98.0% | S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS. | ||||||||||||||||||||
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References
- [1]. Handy RL, Wallace P, Moore PK. Inhibition of nitric oxide synthase by isothioureas: cardiovascular and antinociceptive effects. Pharmacol Biochem Behav. 1996 Oct;55(2):179-84. [Content Brief]
- [2]. A Vromen, et al. Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock. J Appl Physiol (1985). 1996 Aug;81(2):707-15. [Content Brief]
