4299-60-9
Chemical Structure
Sulfisoxazole diethanolamine
Synonym(s): Sulfafurazole diethanolamine
- CAS No.: 4299-60-9
- Formula:C15H24N4O5S
- Molecular Weight:372.44
IUPAC Name: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide compound with 2,2'-azanediylbis(ethan-1-ol) (1:1)
InChIKey: FEPTXVIRMZIGFY-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O.OCCNCCO
Biological Activity: Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
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Sulfisoxazole diethanolamine | Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A. | |||||||||||||||||||||
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References
- [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [Content Brief]
- [2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387. [Content Brief]
