432016-77-8
432016-77-8
Chemical Structure
W2476
- CAS No.: 432016-77-8
- Formula:C15H15N5O2
- Molecular Weight:297.31
IUPAC Name: 1-(4-(2-(6-amino-9H-purin-9-yl)ethoxy)phenyl)ethan-1-one
InChIKey: ONZGILNKQYWMNI-UHFFFAOYSA-N
SMILES: O=C(C)C1=CC=C(C=C1)OCCN2C=NC3=C2N=CN=C3N
Biological Activity: W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1). W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model[1][2].
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W2476 | W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1). W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model. | |||||||||||||||||||||
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References
- [1]. Li, T., et al., (2017). W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica, 38(7), 1024-1037. [Content Brief]
- [2]. Zhong, L., et al., (2021). W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319. Chemical biology & drug design, 97(5), 1089-1099. [Content Brief]
