4350-07-6
Chemical Structure
D-5-Hydroxytryptophan
Synonym(s): D-5-HTP; 5-Hydroxy-D-tryptophan
- CAS No.: 4350-07-6
- Formula:C11H12N2O3
- Molecular Weight:220.23
IUPAC Name: (R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
InChIKey: LDCYZAJDBXYCGN-SECBINFHSA-N
SMILES: O=C(O)[C@H](N)CC1=CNC2=C1C=C(O)C=C2
Biological Activity: D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range[1][2][3].
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D-5-Hydroxytryptophan | D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range. | |||||||||||||||||||||
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References
- [1]. J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22. [Content Brief]
- [2]. Acton G. Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors. Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):129-32. [Content Brief]
- [3]. Shimomura K, et al. Backward walking induced by L-5-hydroxytryptophan in mice. Jpn J Pharmacol. 1981 Feb;31(1):39-46. [Content Brief]
