438481-33-5
438481-33-5
Chemical Structure
Syntelin
- CAS No.: 438481-33-5
- Formula:C21H20N6O2S3
- Molecular Weight:484.62
IUPAC Name: 2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid
InChIKey: SPRISILOMIVCIR-UHFFFAOYSA-N
SMILES: O=C(CSC1=NN=C(N1C2=CC=CC=C2)CSC3=NC(N)=C4C5=C(SC4=N3)CCCC5)O
Biological Activity: Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC50 at 160 nM. Syntelin has antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Syntelin | 98.25% | Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC50 at 160 nM. Syntelin has antitumor activity. | ||||||||||||||||||||
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References
- [1]. Xue biao Yao, et al. Small molecule inhibitor syntelin against kinetochore motor protein cenp-e and use thereof. WO2012062044A1. 2012-05-18. [Content Brief]
- [2]. Mullen M, et al. Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis. J Mol Cell Biol. 2022 Jan 21;13(11):834-837. [Content Brief]
