441060-02-2
441060-02-2
Chemical Structure
CRF1 receptor antagonist-2
- CAS No.: 441060-02-2
- Formula:C22H27ClN4O
- Molecular Weight:398.93
InChIKey: LDIOUQIXNSSOGU-UHFFFAOYSA-N
SMILES: ClC1=C(C2=C3N=C4C(CCC4)=C(N3N=C2C)NC(CC)CC)C=CC(OC)=C1
Biological Activity: CRF1 receptor antagonist-2 is an orally active, blood-brain barrier permeable CRF1 receptor antagonist, with an IC50 of 4 nM in CHO-K1 cell membranes and an IC50 of 7 nM in rat brain cell membranes. CRF1 receptor antagonist-2 exerts anxiolytic effects in swim stress-loaded rats. CRF1 receptor antagonist-2 can be used in studies related to stress-induced anxiety[1].
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CRF1 receptor antagonist-2 | CRF1 receptor antagonist-2 is an orally active, blood-brain barrier permeable CRF1 receptor antagonist, with an IC50 of 4 nM in CHO-K1 cell membranes and an IC50 of 7 nM in rat brain cell membranes. CRF1 receptor antagonist-2 exerts anxiolytic effects in swim stress-loaded rats. CRF1 receptor antagonist-2 can be used in studies related to stress-induced anxiety. | |||||||||||||||||||||
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