441742-93-4
Chemical Structure
Pyrimidine-indole hybrid
- CAS No.: 441742-93-4
- Formula:C20H19N5S
- Molecular Weight:361.46
IUPAC Name: (E)-4-(2-((2-methyl-1H-indol-3-yl)methylene)hydrazinyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine
InChIKey: PXGOXWFKJISRDU-AUEPDCJTSA-N
SMILES: CC(NC1=C2C=CC=C1)=C2/C=N/NC3=C4C5=C(SC4=NC=N3)CCCC5
Biological Activity: Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics[1].
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Pyrimidine-indole hybrid | Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics. | |||||||||||||||||||||
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