445489-49-6
Chemical Structure
Nicotinamide riboside triflate
- CAS No.: 445489-49-6
- Formula:C12H15F3N2O8S
- Molecular Weight:404.32
IUPAC Name: 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium trifluoromethanesulfonate
InChIKey: ZEWRNTDQENDMQK-IVOJBTPCSA-N
SMILES: NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.O=S(C(F)(F)F)([O-])=O
Biological Activity: Nicotinamide riboside triflate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside triflate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside triflate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
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Nicotinamide riboside triflate | Nicotinamide riboside triflate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside triflate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside triflate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease. | |||||||||||||||||||||
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Nicotinamide riboside-d4 triflate | Nicotinamide riboside-d4 (triflate) (Nicotinamide riboside-d4 triflate (d3-major)a/b mixture) is deuterium labeled Nicotinamide riboside (triflate). | |||||||||||||||||||||
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References
- [1]. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. [Content Brief]
- [2]. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. [Content Brief]
