445493-22-1
445493-22-1
Chemical Structure
Pladienolide A
- CAS No.: 445493-22-1
- Formula:C28H46O7
- Molecular Weight:494.66
InChIKey: LTXWIJFJMWETHY-VZSAGGBRSA-N
SMILES: C/C([C@@H]1[C@H](/C=C/[C@@H]([C@](O)(CC[C@H](CC(O1)=O)O)C)O)C)=C\C=C\[C@@H](C)C[C@@H]2[C@@](O2)([H])[C@H](C)[C@@H](O)CC
Biological Activity: Pladienolide A is a natural product derived from Streptomyces platensis. Pladienolide A inhibits hypoxia-induced VEGF promoter-driven PLAP reporter gene. Pladienolide A can be used for research on glioma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pladienolide A | 98.01% | Pladienolide A is a natural product derived from Streptomyces platensis. Pladienolide A inhibits hypoxia-induced VEGF promoter-driven PLAP reporter gene. Pladienolide A can be used for research on glioma. | ||||||||||||||||||||
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References
- [1]. Effenberger KA, et al. Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs. The Journal of biological chemistry. 2014 Jan 24;289(4):1938-47. [Content Brief]
- [2]. Sakai T, et al. Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. J Antibiot (Tokyo). 2004 Mar;57(3):173-179.
