451492-95-8
451492-95-8
Chemical Structure
AV-412 free base
Synonym(s): MP-412 free base
- CAS No.: 451492-95-8
- Formula:C27H28ClFN6O
- Molecular Weight:507.00
IUPAC Name: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide
InChIKey: ZAJXXUDARPGGOC-UHFFFAOYSA-N
SMILES: O=C(C=C)NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1C#CC(C)(C)N(CC4)CCN4C
Biological Activity: AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AV-412 free base | 98.10% | AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively. | ||||||||||||||||||||
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AV-412 free base (Standard) | ≥98% | AV-412 free base (Standard) is the analytical standard of AV-412 free base (HY-10346A). This product is intended for research and analytical applications. AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively. | ||||||||||||||||||||
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