4548-34-9
4548-34-9
Chemical Structure
(1S,2R)-Tranylcypromine hydrochloride
Synonym(s): (1S,2R)-SKF 385 hydrochloride
- CAS No.: 4548-34-9
- Formula:C9H12ClN
- Molecular Weight:169.65
IUPAC Name: (1S,2R)-2-phenylcyclopropan-1-amine hydrochloride
InChIKey: ZPEFMSTTZXJOTM-RJUBDTSPSA-N
SMILES: N[C@H]1C[C@@H]1C2=CC=CC=C2.[H]Cl
Biological Activity: (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. (1S,2R)-Tranylcypromine hydrochloride can inhibits MAO and LSD1[1][2].
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(1S,2R)-Tranylcypromine hydrochloride | (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. (1S,2R)-Tranylcypromine hydrochloride can inhibits MAO and LSD1. | |||||||||||||||||||||
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References
- [1]. TetsuyaEzawa, et al. Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine. Tetrahedron: Asymmetry. 15 December 2017;28(12):1690-1699.
- [2]. Valente S, et al. Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. ACS Med Chem Lett. 2014 Dec 8;6(2):173-7. [Content Brief]
